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5–four μmol/L assortment,[156][157] the focus of serotonin in synaptic vesicles was calculated at 270 mM.[182] subsequent vesicular release, the ensuing concentration of serotonin in the synaptic cleft, to which serotonin receptors are exposed, is estimated being about 300 μmol/L. So, whilst in vitro receptor binding affinities, efficacies, a